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- Statistical & Bio Seminar
- Mechanical synchronization of beating within and between cardiomyocytes
- Prof. Samuel Safran
28/05/2017, 14:30 - 15:30
- Yariv Kafri
We present theoretical models and predictions of how mechanics due to elastic interactions in actively beating heart cells can lead to synchronization of beating both within a single cells and between nearby cells and show theoretically how the experimentally measured substrate rigidity dependence of the cell structure can be mapped onto measurements of the beating strain [1, 2]. This suggests that the correlated beating of heart cells may be limited by the structural registry of the myofibrils which in turn is regulated by their elastic environment.
Recent experiments  on synchronization of beating of two nearby cardiomyocytes have shown that a mechanical probe can “pace” a beating cell to within about twice or a quarter of its natural beating frequency. This is indicative of how nearby cardiomyocytes embedded can regulate their mutual beating. We focus theoretically  on the synchronization of two nearby cardiomyocyte cells or a cell and a mechanical probe and show that based on elastic interactions alone, two nearby cells can synchronize their phase and frequency in a manner that depends on their mutual orientation. Using non-linear dynamics approaches, the theory predicts the persistence time of cells whose beating is either spontaneous or entrained by a mechanical probe
 S. Majkut et al., Current Biology, 23, 2323 (2013).
 K. Dasbiswas, et al., Nature Comm., 6, 7085 (2015).
 I. Nitsan et al., Nature Physics, 12, 472 (2016).
 O. Cohen and S. A. Safran, Soft Matter, 12, 6088 (2016) and to be published.
Collaborations: Theory – Kinjal Dasbiswas, Ohad Cohen (Weizmann Institute of Science);
Experiment – Dennis Discher, Stephanie Majkut (Penn); Shelly Tzlil (Technion)