Stochasticity of Intracellular Transport

TYPECondensed Matter Seminar
Speaker:Stanislav Burov
Affiliation:Chicago University
Location:Lidow Nathan Rosen (300)
Abstract:This talk will describe quantitative analyses of particle tracking data for
systems with cytoskeletally associated motors to better understand the
motions contributing to intracellular transport and, more generally, means
for characterizing systems far from equilibrium. We exploit stochastic properties
of single particle trajectories to establish "sanity" tests for experimentally
collected data. Development of simple order parameters for 2d motion
and studying its behavior for different models of transport in disordered media
permits us to distinguish between random motion inside dense physical systems
and molecular motors mediated transport. Furthermore, the stochastic properties
of insulin-containg vesicles transport in beta cells provide a simple mechanism for how
important beta cell functioning (biphasic insulin secretion) can arise.