Interactions and Complexity of Small RNA |
TYPE | Colloquium |
Speaker: | Prof. Erel Levine |
Affiliation: | Department of Physics and FAS Center for Systems Biology, Harvard UniversityOver the last years it h |
Date: | 03.11.2014 |
Time: | 14:30 |
Location: | Lidow Rosen Auditorium (323) |
Abstract: | Over the last years it had become clear that small RNA molecules play a central role in biology that has been overlooked for decades. Small RNA systems are characterized by high density of interactions at multiple scales, that collectively give rise to function. In this talk I will describe our efforts to to learn how small RNA regulatory functions stem from the structure of these underlying interactions. After a brief review of the relevant biology, I will first address the question how intra-molecular interactions determine the functional properties of a small RNA, using a combination of quantitative large-scale experiment and data-driven modeling. I will then turn to discuss how the evolutionary imprint of genetic interactions can be used to uncover regulatory strategies by solving an inverse problem of statistical mechanics. |